Co-Lead, Project 5
Assistant Professor, Department of Psychiatry
Virginia Commonwealth University
E-mail: tanhoang.nguyen@vcuhealth.org
Statistics, Bioinformatics, Integrative analysis, Neurodevelopmental and psychiatric disorders, Substance use disorders, Structural variation, Systems biology
Han S, Sun X, Sloofman L, Satterstrom FK, Xu X, Liang L, Knoblauch N, Sheng W, Zhao S, Nguyen TH, Wang G, Buxbaum J, He X. MIRAGE: A Bayesian statistical method for gene-level rare-variant analysis incorporating functional annotations. Am J Hum Genet. 2026 Jan 8;113(1):168-183.
Kealhofer M, Brown R, Riley BP, Nguyen TH. Joint analysis of de novo mutations from autism spectrum disorder, schizophrenia, congenital heart disease, and other developmental disorders improves detection power and implicates shared molecular pathways and CNS processes. NAR Genom Bioinform. 2025 Dec;7(4):lqaf162.
Nguyen T, Coleman J, Gentry A, Webb B, Peterson R, Kendler K, Riley B, Amstadter A, Sheerin C. F3. RARE VARIANT ANALYSIS FOR POST- TRAUMATIC STRESS DISORDER USING WHOLE-EXOME-SEQUENCING DATA. European Neuropsychopharmacology. 2024 October; 87:207-208.
Strom NI, Verhulst B, Bacanu SA, et al. Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling. medRxiv. 2024 Jul 5;. doi: 10.1101/2024.07.03.24309466.
Ahangari M, Gentry AE, Hassan MF, Nguyen TH, Kendler KS, Bacanu SA, Peterson RE, Riley BP, Webb BT. Improving the discovery of rare variants associated with alcohol problems by leveraging machine learning phenotype prediction and functional information. bioRxiv. 2023 Sep 15;. doi: 10.1101/2023.09.11.557163.
Ahangari M, Bustamante D, Kirkpatrick R, Nguyen TH, Verrelli BC, Fanous A, Kendler KS, Webb BT, Bacanu SA, Riley BP. Relationship between polygenic risk scores and symptom dimensions of schizophrenia and schizotypy in multiplex families with schizophrenia. Br J Psychiatry. 2023 Jul;223(1):301-308.
Liu D, Meyer D, Fennessy B, et al. Schizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations. Nat Genet. 2023 Mar;55(3):369-376.
Ahangari M, Kirkpatrick R, Nguyen TH, Gillespie N, Kendler KS, Bacanu SA, Webb BT, Verrelli BC, Riley BP. Examining the source of increased bipolar disorder and major depressive disorder common risk variation burden in multiplex schizophrenia families. Schizophrenia (Heidelb). 2022 Nov 25;8(1):106.
Ahangari M, Gentry AE, Nguyen TH, Kirkpatrick R, Verrelli BC, Bacanu SA, Kendler KS, Webb BT, Riley BP. Evaluating the role of common risk variation in the recurrence risk of schizophrenia in multiplex schizophrenia families. Transl Psychiatry. 2022 Jul 21;12(1):291.
Ahangari M, Everest E, Nguyen TH, Verrelli BC, Webb BT, Bacanu SA, Tahir Turanli E, Riley BP. Genome-wide analysis of schizophrenia and multiple sclerosis identifies shared genomic loci with mixed direction of effects. Brain Behav Immun. 2022 Aug;104:183-190. doi: 10.1016/j.bbi.2022.06.007.
Nguyen TH, He X, Brown RC, Webb BT, Kendler KS, Vladimirov VI, Riley BP, Bacanu SA. DECO: a framework for jointly analyzing de novo and rare case/control variants, and biological pathways. Brief Bioinform. 2021 Sep 2;22(5).
Blokland GAM, Grove J, Chen CY, et al. Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders. Biol Psychiatry. 2022 Jan 1;91(1):102-117.
Jia X, Goes FS, Locke AE, et al. Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder. Mol Psychiatry. 2021 Sep;26(9):5239-5250.
Nguyen TH, Dobbyn A, Brown RC, Riley BP, Buxbaum JD, Pinto D, Purcell SM, Sullivan PF, He X, Stahl EA. mTADA is a framework for identifying risk genes from de novo mutations in multiple traits. Nat Commun. 2020 Jun 10;11(1):2929.
Huckins LM, Chatzinakos C, Breen MS, et al. Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene, SNRNP35, Specific to Military Cohorts. Cell Rep. 2020 Jun 2;31(9):107716.
Stahl EA, Breen G, Forstner AJ, et al. Genome-wide association study identifies 30 loci associated with bipolar disorder. Nat Genet. 2019 May;51(5):793-803.
Huckins LM, Dobbyn A, Ruderfer DM, Hoffman G, Wang W, Pardiñas AF, Rajagopal VM, Als TD, T Nguyen H, Girdhar K, Boocock J, Roussos P, Fromer M, Kramer R, Domenici E, Gamazon ER, Purcell S, Demontis D, Børglum AD, Walters JTR, O'Donovan MC, Sullivan P, Owen MJ, Devlin B, Sieberts SK, Cox NJ, Im HK, Sklar P, Stahl EA. Gene expression imputation across multiple brain regions provides insights into schizophrenia risk. Nat Genet. 2019 Apr;51(4):659-674.
Nguyen HT, Bryois J, Kim A, Dobbyn A, Huckins LM, Munoz-Manchado AB, Ruderfer DM, Genovese G, Fromer M, Xu X, Pinto D, Linnarsson S, Verhage M, Smit AB, Hjerling-Leffler J, Buxbaum JD, Hultman C, Sklar P, Purcell SM, Lage K, He X, Sullivan PF, Stahl EA. Integrated Bayesian analysis of rare exonic variants to identify risk genes for schizophrenia and neurodevelopmental disorders. Genome Med. 2017 Dec 20;9(1):114.