2017

Variation in SWI/SNF chromatin remodeling complex proteins is associated with alcohol dependence and antisocial behavior in human populations

Variation in SWI/SNF chromatin remodeling complex proteins is associated with alcohol dependence and antisocial behavior in human populations

October 5, 2017

Mathies LD, Aliev F, COGA Investigators, Davies AG, Dick DM, Bettinger JC
Alcohol. Clin. Exp. Res. 2017 doi: 10.1111/acer.13514. PMID: 28981154 

Intermittent ethanol during adolescence leads to lasting behavioral changes in adulthood and alters gene expression and histone methylation in the PFC

Intermittent ethanol during adolescence leads to lasting behavioral changes in adulthood and alters gene expression and histone methylation in the PFC

September 26, 2017

Wolstenholme JT, Mahmood T, Harris GM, Abbas S, Miles MF
Front Mol. Neurosci. 2017 10:307. doi: 10.3389/fnmol.2017.00307. PMCID: PMC5622951

Molecular genetic influences on normative and problematic alcohol use in a population-based sample of college students.

Molecular genetic influences on normative and problematic alcohol use in a population-based sample of college students.

March 15, 2017

Webb BT, Edwards AC, Wolen AR, Salvatore JE, Aliev F, Riley BP, Sun C, Williamson VS, Kitchens JN, Pedersen K, Adkins A, Cooke ME, Savage JE, Neale Z, Cho SB, Dick DM, Kendler KS
Front Genet. 2017 8:30. doi: 10.3389/fgene.2017.00030. PMCID: PMC5350109

Genomewide association study of alcohol dependence identifies risk loci altering ethanol-response behaviors in model organisms

Genomewide association study of alcohol dependence identifies risk loci altering ethanol-response behaviors in model organisms

February 22, 2017

Adkins AE, Hack LM, Bigdeli TB, Williamson VS, McMichael GO, Mamdani M, Edwards AC, Aliev F, Chan RF, Bhandari P, Raabe RC, Alaimo JT, Blackwell GG, Moscati A, Poland RS, Rood B, Patterson DG, Walsh D; Collaborative Study of the Genetics of Alcoholism Consortium., Whitfield JB, Zhu G, Montgomery GW, Henders AK, Martin NG, Heath AC, Madden PA, Frank J, Ridinger M, Wodarz N, Soyka M, Zill  P, Ising M, Nöthen MM, Kiefer F, Rietschel M; The German Study of the Genetics of Addiction Consortium., Gelernter J, Sherva R, Koesterer R, Almasy L, Zhao H, Kranzler HR, Farrer LA, Maher BS, Prescott CA, Dick DM, Bacanu SA, Mathies LD, Davies AG, Vladimirov VI, Grotewiel M, Bowers MS, Bettinger JC, Webb BT, Miles MF, Kendler KS, Riley BP
Alcohol Clin Exp Res. 2017 doi: 10.1111/acer.13362. PMID: 28226201

The rate of change in alcohol misuse across adolescence is heritable.

The rate of change in alcohol misuse across adolescence is heritable.

January 1, 2017

Edwards AC, Heron J, Vladimirov V, Wolen AR, Adkins DE, Aliev F, Hickman M, Kendler KS
Alcohol Clin Exp Res. 2017 Jan;41(1):57-64. doi: 10.1111/acer.13262. PMID: 27892595

 2016

The allostatic impact of chronic ethanol on gene expression: A genetic analysis of chronic intermittent ethanol treatment in the BXD cohort.

The allostatic impact of chronic ethanol on gene expression: A genetic analysis of chronic intermittent ethanol treatment in the BXD cohort.

November 1, 2016

van der Vaart AD, Wolstenholme JT, Smith ML, Harris GM, Lopez MF, Wolen AR, Becker HC, Williams RW, Miles MF
Alcohol 2016 Nov 1. pii: S0741-8329(15)30152-X. doi:10.1016/j.alcohol.2016.07.010. PMID: 27838001

Genetic influences on adolescent behavior

Genetic influences on adolescent behavior

November 1, 2016

Dick DM, Adkins AE Kuo SI
Neurosci Biobehav Rev 2016 70:198-205. doi: 10.1016/j.neubiorev.2016.07.007. PMCID: PMC5074858

Variable effects of chronic intermittent ethanol exposure on ethanol drinking in a genetically diverse mouse cohort.

Variable effects of chronic intermittent ethanol exposure on ethanol drinking in a genetically diverse mouse cohort.

October 13, 2016

Lopez MF, Miles, MF, Williams RW, Becker HC
2016 Alcohol doi: 10.1016/j.alcohol.2016.09.003. PMID: 27793543.

Ibudilast attenuates expression of behavioral sensitization to cocaine in male and female rats.

Ibudilast attenuates expression of behavioral sensitization to cocaine in male and female rats.

October 1, 2016

Poland RS, Hahn YK, Knapp PE, Beardsley PM, Bowers MS
2016 Neuropharmacology. 109:281-92. doi: 10.1016/j.neuropharm.2016.06.024. PMCID: PMC5404892.

Disentangling the Role of Astrocytes in Alcohol Use Disorder

Disentangling the Role of Astrocytes in Alcohol Use Disorder

September 1, 2016

Adermark L, Bowers MS
2016 Alcohol. Clin. Exp. Res. 40(9):1802-1816. doi: 10.1111/acer.13168. PMID: 27476876.

The genetics of addiction; Where do we go from here?

The genetics of addiction; Where do we go from here?

September 1, 2016

Dick DM
2016 J. Stud. Alcohol Drugs 77:673-675 doi: 10.15288/jsad.2016.77.673. PMID: 27588521

 

Predicting tobacco use across the first year of college.

Predicting tobacco use across the first year of college.

July 1, 2016

Cooke ME, Nasim, A, Cho SB, Kendler, KS, Clark, SL, Dick DM
2016 Am. J. Health Behav. 40(4):484-495 doi: 10.5993/AJHB.40.4.10. PMCID: PMC4946338.

A prospective longitudinal model predicting early adult alcohol problems: evidence for a robust externalizing pathway.

A prospective longitudinal model predicting early adult alcohol problems: evidence for a robust externalizing pathway.

April 1, 2016

Edwards AC, Gardner CO, Hickman M, Kendler KS
2016 Psychol Med. 46(5):957-68. doi:10.1017/S0033291715002457. PMCID: PMC4801516.

Identification of quantitative trait loci and candidate genes for an anxiolytic-like response to ethanol in BXD recombinant inbred strains

Identification of quantitative trait loci and candidate genes for an anxiolytic-like response to ethanol in BXD recombinant inbred strains

March 1, 2016

Putman AH, Wolen AR, Harenza JL, Yordanova RK, Webb BT, Chesler EJ, Miles MF.
2016 Genes Brain Behav. 15(4):367-81. doi: 10.1111/gbb.12289. PMCID: PMC4852167.

N-acetylcysteine decreased nicotine reward-like properties and withdrawal in mice.

N-acetylcysteine decreased nicotine reward-like properties and withdrawal in mice.

March 1, 2016

Bowers MS, Jackson A, Maldoon PP, Damaj MI
2016 Psychopharmacology (Berl). 233(6):995-1003. doi: 10.1007/s00213-015-4179-4. PMCID: PMC4819399.

JEPEGMIX: gene-level joint analysis of functional SNPs in cosmopolitan cohorts.

JEPEGMIX: gene-level joint analysis of functional SNPs in cosmopolitan cohorts.

January 15, 2016

Lee D, Williamson VS, Bigdeli TB, Riley BP, Webb BT, Fanous AH,Kendler KS, Vladimirov VI, Bacanu SA
2016 Bioinformatics 32(2):295-297. doi: 10.1093/bioinformatics/btv567. PMCID: PMC4708106

Time-Course Analysis of Brain Regional Expression Network Responses to Chronic Intermittent Ethanol and Withdrawal: Implications for Mechanisms Underlying Excessive Ethanol Consumption.

Time-Course Analysis of Brain Regional Expression Network Responses to Chronic Intermittent Ethanol and Withdrawal: Implications for Mechanisms Underlying Excessive Ethanol Consumption.

January 5, 2016

Maren L. Smith, Marcelo F. Lopez, Kellie J. Archer, Aaron R. Wolen, Howard C. Becker, Michael F. Miles
2016 PLoS One 11(1):e0146257. doi: 10.137/journal.pone.0146257. PMCID: PMC4701666

Nicotine Enhances the Hypnotic and Hypothermic Effects of Alcohol in the Mouse.

Nicotine Enhances the Hypnotic and Hypothermic Effects of Alcohol in the Mouse.

January 1, 2016

Slater CA, Jackson A, Muldoon PP, Dawson A, O'Brien M, Soll LG, Abdullah R, Carroll FI, Tapper AR, Miles MF, Banks ML, Bettinger JC, Damaj IM.
2016 Alcohol Clin Exp Res. 40(1):62-72. doi: 10.1111/acer.12918. PMCID: PMC4700556.

 
2015

Applying the new genomics to alcohol dependence.

Applying the new genomics to alcohol dependence.

December 1, 2015

Farris SP, Pietrzykowski AZ, Miles MF, O'Brien MA, Sanna PP, Zakhari S, Mayfield RD, Harris RA.
2015 Alcohol. 49(8):825-36. doi: 10.1016/j.alcohol.2015.03.001. PMCID: PMC4586299

Patterns of Substance Use Across the First Year of College and Associated Risk Factors.

Patterns of Substance Use Across the First Year of College and Associated Risk Factors.

October 27, 2015

Cho SB, Llaneza DC, Adkins AE, Cooke M, Kendler KS, Clark SL, Dick DM.
2015 Front Psychiatry. 6:152. doi: 10.3389/fpsyt.2015.00152. PMCID: PMC4621385.

Level of response to alcohol as a factor for targeted prevention in college students.

Level of response to alcohol as a factor for targeted prevention in college students.

November 1, 2015

Savage JE, Neale Z, Cho SB, Hancock L, Kalmijn JA, Smith TL, Schuckit MA, Donovan KK, Dick DM.
2015 Alcohol Clin Exp Res. 39(11):2215-23. doi: 10.1111/acer.12874. PMCID: PMC4624230.

Rodent Brain Microinjection to Study Molecular Substrates of Motivated Behavior.

Rodent Brain Microinjection to Study Molecular Substrates of Motivated Behavior.

September 16, 2015

Poland RS, Bull C, Syed WA, Bowers MS
2015 J Vis Exp. (103). doi:10.3791/53018. PMCID: PMC4692606.

Integrating mRNA and miRNA Weighted Gene Co-Expression Networks with eQTLs in the Nucleus Accumbens of Subjects with Alcohol Dependence

Integrating mRNA and miRNA Weighted Gene Co-Expression Networks with eQTLs in the Nucleus Accumbens of Subjects with Alcohol Dependence

September 18, 2015

Mamdani M, Williamson V, McMichael GO, Blevins T, Aliev F, Adkins A, Hack L, Bigdeli T, van der Vaart AD, Web BT, Bacanu SA, Kalsi G; COGA Consortium, Kendler KS, Miles MF, Dick D, Riley BP, Dumur C, Vladimirov VI.
2015 PLoS One. 10(9):e0137671. doi: 10.1371/journal.pone.0137671. PMCID: PMC4575063.

Nicotinic receptor contributions to smoking: insights from human studies and animal models.

Nicotinic receptor contributions to smoking: insights from human studies and animal models.

March 1, 2015

Brunzell DH, Stafford AM, Dixon CI
2015 Curr Addict Rep 2(1):33-46. PMCID: PMC4540370.

Translating Alcohol Research: Opportunities and Challenges

Translating Alcohol Research: Opportunities and Challenges

June 1, 2015

Batman AM, Miles MF.
2015 Alcohol Res. 37(1):7-14. PMCID: PMC4476605

Oral operant ethanol self-administration in the absence of explicit cues, food restriction, water restriction and ethanol fading in C57BL/6J mice.

Oral operant ethanol self-administration in the absence of explicit cues, food restriction, water restriction and ethanol fading in C57BL/6J mice.

August 14, 2015

Stafford AM, Anderson SM, Shelton KL, Brunzell DH
2015 Psychopharmacology (Berl). 232(20):3783-95. doi: 10.1007/s00213-015-4040-9. PMCID: PMC4667783.

The stability and predictors of peer group deviance in university students.

The stability and predictors of peer group deviance in university students.

September 1, 2015

Kendler KS, Myers J, Dick D.
2015 Soc Psychiatry Psychiatr Epidemiol. 50(9):1463-70. doi: 10.1007/s00127-015-1031-4. PMCID: PMC4546573

Overlapping genetic and environmental influences among men's alcohol consumption and problems, romantic quality and social support.

Overlapping genetic and environmental influences among men's alcohol consumption and problems, romantic quality and social support.

August 1, 2015

Salvatore JE, Prom-Wormley E, Prescott CA, Kendler KS.
2015 Psychol Med. 45(11):2353-64. doi:10.1017/S003329171500029X. PMCID: PMC4499011

Sex differences in the pathways to symptoms of alcohol use disorder: a study of opposite-sex twin pairs.

Sex differences in the pathways to symptoms of alcohol use disorder: a study of opposite-sex twin pairs.

April 6, 2015

Kendler KS, Edwards AC, Gardner CO
2015 
Alcohol Clin Exp Res. 39(6):998-1007. doi: 10.1111/acer.12694. PMCID: PMC4452423.

<i>Drosophila</i> and <i>Caenorhabditis elegans</i> as Discovery Platforms for Genes Involved in Human Alcohol Use Disorder.

Drosophila and Caenorhabditis elegans as Discovery Platforms for Genes Involved in Human Alcohol Use Disorder.

August 1, 2015

Grotewiel M, Bettinger JC
2015 Alcohol Clin Exp Res. 39(8):1292-311. doi: 10.1111/acer.12785. PMCID: PMC4656040.

The predictive power of family history measures of alcohol and drug problems and internalizing disorders in a college population

The predictive power of family history measures of alcohol and drug problems and internalizing disorders in a college population

July 1, 2015

Kendler KS, Edwards A, Myers J, Cho SB, Adkins A, Dick D.
2015 Am J Med Genet B Neuropsychiatr Genet. 168B(5):337-46. doi: 10.1002/ajmg.b.32320. PMCID: PMC4466079

DISTMIX: direct imputation of summary statistics for unmeasured SNPs from mixed ethnicity cohorts.

DISTMIX: direct imputation of summary statistics for unmeasured SNPs from mixed ethnicity cohorts.

October 1, 2015

Lee D, Bigdeli TB, Williamson VS, Vladimirov VI, Riley BP, Fanous AH, Bacanu SA
2015 
Bioinformatics. 31(19):3099-104. doi:10.1093/bioinformatics/btv348. PMCID: PMC4576696.

An inexpensive, scalable behavioral assay for measuring ethanol sedation sensitivity and rapid tolerance in <i>Drosophila</i>.

An inexpensive, scalable behavioral assay for measuring ethanol sedation sensitivity and rapid tolerance in Drosophila.

April 15, 2015

Sandhu S, Kollah AP, Lewellyn L, Chan RF, Grotewiel M.
2015 J Vis Exp. (98) e52676. doi: 10.3791/52676.PMCID: PMC4423423

An Assay for Measuring the Effects of Ethanol on the Locomotion Speed of <i>Caenorhabditis elegans</i>

An Assay for Measuring the Effects of Ethanol on the Locomotion Speed of Caenorhabditis elegans

April 9, 2015

Davies AG, Blackwell GG, Raabe RC, Bettinger JC.
2015 J Vis Exp. 2015 Apr 9;(98). doi: 10.3791/52681. PMCID:PMC4476067

Addiction resistance: Definition, validation and association with mastery.

Addiction resistance: Definition, validation and association with mastery.

September 1, 2015

Kendler KS, Myers J
2015 Drug Alcohol Depend. 154:236-42. doi:10.1016/j.drugalcdep.2015.06.043. PMCID: PMC4575813.

Differential response of glial fibrillary acidic protein-positive astrocytes in the rat prefrontal cortex following ethanol self-administration.

Differential response of glial fibrillary acidic protein-positive astrocytes in the rat prefrontal cortex following ethanol self-administration.

April 1, 2015

Bull C, Syed WA, Minter SC, Bowers MS
2015 
Alcohol Clin Exp Res 39(4):650-8. doi: 10.1111/acer.12683. PMCID: PMC4384186.

 

The heritability of alcohol use disorders: a meta-analysis of twin and adoption studies.

The heritability of alcohol use disorders: a meta-analysis of twin and adoption studies.

April 1, 2015

Verhulst B, Neale MC, Kendler KS.
2015 Psychol Med. 45(5):1061-72. doi: 10.1017/S0033291714002165. PMCID: PMC4345133

SWI/SNF chromatin remodeling regulates alcohol response behaviors in <i>Caenorhabditis elegans</i> and is associated with alcohol dependence in humans.

SWI/SNF chromatin remodeling regulates alcohol response behaviors in Caenorhabditis elegans and is associated with alcohol dependence in humans.

March 10, 2015

Mathies LD, Blackwell GG, Austin MK, Edwards AC, Riley BP, Davies AG, Bettinger JC.
2015 Proc Natl Acad Sci U S A. 112(10):3032-7. doi: 10.1073/pnas.1413451112. PMCID: PMC4364201.

An extended Swedish national adoption study of alcohol use disorder.

An extended Swedish national adoption study of alcohol use disorder.

March 10, 2015

Kendler KS, Ji J, Edwards AC, Ohlsson H, Sundquist J, Sundquist K
2015 JAMA Psychiatry. 72(3):211-8. doi: 10.1001/jamapsychiatry.2014.2138. PMCID: PMC4351126

KCNN Genes that Encode Small-Conductance Ca<sup>2+</sup>-Activated K<sup>+</sup> Channels Influence Alcohol and Drug Addiction.

KCNN Genes that Encode Small-Conductance Ca2+-Activated K+ Channels Influence Alcohol and Drug Addiction.

March 4, 2015

Padula AE, Griffin WC 3rd, Lopez MF, Nimitvilai S, Cannady R, McGuier NS, Chesler EJ, Miles MF, Williams RW, Randall PK, Woodward JJ, Becker HC, Mulholland PJ.
2015 Neuropsychopharmacology 40(8):1928-39. doi:10.1038/npp.2015.42. PMID: 25662840

Endophenotypes for Alcohol Use Disorder: An Update on the Field

Endophenotypes for Alcohol Use Disorder: An Update on the Field

March 1, 2015

Salvatore JE, Gottesman II, Dick DM.
2015 Curr Addict Rep. 2(1):76-90. PMCID: PMC4520241

A novel cholinergic action of alcohol and the development of tolerance to that effect in <i>Caenorhabditis elegans</i>.

A novel cholinergic action of alcohol and the development of tolerance to that effect in Caenorhabditis elegans.

January 1, 2015

Hawkins EG, Martin I, Kondo LM, Judy ME, Brings VE, Chan CL, Blackwell GG, Bettinger JC, Davies AG.
2015 Genetics 199(1):135-49. doi: 10.1534/genetics.114.171884. PMCID: PMC4286678

JEPEG: a summary statistics based tool for gene-level joint testing of functional variants.

JEPEG: a summary statistics based tool for gene-level joint testing of functional variants.

April 15, 2015

Lee D, Williamson VS, Bigdeli TB, Riley BP, Fanous AH, Vladimirov VI, Bacanu SA.
2015 Bioinformatics 31(8):1176-82. doi:10.1093/bioinformatics/btu816. PMCID: PMC4393522.

 

 
2014

Molecular and neurologic responses to chronic alcohol use.

Molecular and neurologic responses to chronic alcohol use.

October 14, 2014

Costin BN, Miles MF
2014 Handb Clin Neurol 125:157-71. doi: 10.1016/B978-0-444-62619-6.00010-0. PMCID: PMC4412740.

Psychiatric resilience: longitudinal twin study.

Psychiatric resilience: longitudinal twin study.

October 1, 2015

Amstadter AB, Myers JM, Kendler KS.
2014 Br J Psychiatry. 205(4):275-80. doi: 10.1192/bjp.bp.113.130906. PMCID: PMC4180845

The α3β4* nicotinic ACh receptor subtype mediates physical dependence to morphine: mouse and human studies.

The α3β4* nicotinic ACh receptor subtype mediates physical dependence to morphine: mouse and human studies.

October 14, 2014

Muldoon PP, Jackson KJ, Perez E, Harenza JL, Molas S, Rais B, Anwar H, Zaveri NT, Maldonado R, Maskos U, McIntosh JM, Dierssen M, Miles MF, Chen X, De Biasi M, Damaj MI.
2014 Br J Pharmacol. 171(16):3845-57. doi: 10.1111/bph.12741. PMCID: PMC4128047

Targeting the Small- and Intermediate-Conductance Ca-Activated Potassium Channels: The Drug-Binding Pocket at the Channel/Calmodulin Interface.

Targeting the Small- and Intermediate-Conductance Ca-Activated Potassium Channels: The Drug-Binding Pocket at the Channel/Calmodulin Interface.

October 14, 2014

Cui M, Qin G, Yu K, Bowers MS, Zhang M
2014 Neurosignals 22(2):65-78. doi:10.1159/000367896. PMCID: PMC4390548.

Socioeconomic status and alcohol-related behaviors in mid- to late adolescence in the Avon Longitudinal Study of Parents and Children.

Socioeconomic status and alcohol-related behaviors in mid- to late adolescence in the Avon Longitudinal Study of Parents and Children.

July 1, 2014

Kendler KS, Gardner CO, Hickman M, Heron J, Macleod J, Lewis G, Dick DM.
2014 J Stud Alcohol Drugs. 75(4):541-5. PMCID: PMC4108596

Romantic relationship status and alcohol use and problems across the first year of college.

Romantic relationship status and alcohol use and problems across the first year of college.

July 1, 2014

Salvatore JE, Kendler KS, Dick DM.
2014 J Stud Alcohol Drugs. 75(4):580-9. PMCID: PMC4108599

Contrasting influences of <i>Drosophila white/mini-white</i> on ethanol sensitivity in two different behavioral assays.

Contrasting influences of Drosophila white/mini-white on ethanol sensitivity in two different behavioral assays.

June 1, 2014

Chan RF, Lewellyn L, DeLoyht JM, Sennett K, Coffman S, Hewitt M, Bettinger JC, Warrick JM, Grotewiel M.
2014 Alcohol Clin Exp Res. 38(6):1582-93. doi: 10.1111/acer.12421. PMCID: PMC4049357

The role of the BK channel in ethanol response behaviors: evidence from model organism and human studies.

The role of the BK channel in ethanol response behaviors: evidence from model organism and human studies.

September 9, 2014

Bettinger JC, Davies AG
2014 Front Physiol 5:346. doi: 10.3389/fphys.2014.00346. PMCID: PMC4158801.

The boundaries of the internalizing and externalizing genetic spectra in men and women.

The boundaries of the internalizing and externalizing genetic spectra in men and women.

February 1, 2014

Kendler KS, Myers J.
2014 Psychol Med. 44(3):647-55. doi: 10.1017/S0033291713000585. PMCID: PMC3825740

Genetic and environmental risk factors for illicit substance use and use disorders: Joint analysis of self and co-twin ratings.

Genetic and environmental risk factors for illicit substance use and use disorders: Joint analysis of self and co-twin ratings.

January 1, 2014

Ystrom E, Reichborn-Kjennerud T, Neale MC, Kendler KS.
2014 Behav Genet. 44(1):1-13. doi: 10.1007/s10519-013-9626-6. PMCID: PMC3893354