Brien Riley

Principle Investigator, Center Project 4
Co-Investigator, Center Project 5
Associate Professor, Department of Psychiatry
Virginia Commonwealth University
Phone: 804-828-8083

Genetics of human alcohol dependence, genomic analysis of psychiatric and neurological disorders

Franke B, Stein JL, Ripke S, Anttila V, Hibar DP, van Hulzen KJ, Arias-Vasquez A, Smoller JW, Nichols TE, Neale MC, McIntosh AM, Lee P, McMahon FJ, Meyer-Lindenberg A, Mattheisen M, Andreassen OA, Gruber O, Sachdev PS, Roiz-Santiañez R, Saykin AJ, Ehrlich S, Mather KA, Turner JA, Schwarz E, Thalamuthu A, Yao Y, Ho YY, Martin NG, Wright MJ; Schizophrenia Working Group of the Psychiatric Genomics Consortium; Psychosis Endophenotypes International Consortium; Wellcome Trust Case Control Consortium 2; Enigma Consortium, O'Donovan MC, Thompson PM, Neale BM, Medland SE, Sullivan PF. Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept. Nat Neurosci. 2016 Mar; 19(3):420-31. doi: 10.1038/nn.4228. Epub 2016 Feb 1. PubMed PMID: 26854805. 

Sekar A, Bialas AR, de Rivera H, Davis A, Hammond TR, Kamitaki N, Tooley K, Presumey J, Baum M, Van Doren V, Genovese G, Rose SA, Handsaker RE; Schizophrenia Working Group of the Psychiatric Genomics Consortium, Daly MJ, Carroll MC, Stevens B, McCarroll SA. Schizophrenia risk from complex variation of complement component 4. Nature. 2016 Feb 11; 530(7589):177-83. doi: 10.1038/nature16549. Epub 2016 Jan 27. PubMed PMID: 26814963; PubMed Central PMCID: PMC4752392. 

Loh PR, Bhatia G, Gusev A, Finucane HK, Bulik-Sullivan BK, Pollack SJ; Schizophrenia Working Group of Psychiatric Genomics Consortium, de Candia TR, Lee SH, Wray NR, Kendler KS, O'Donovan MC, Neale BM, Patterson N, Price AL. Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis. Nat Genet. 2015 Dec; 47(12):1385-92. doi: 10.1038/ng.3431. Epub 2015 Nov 2. PubMed PMID: 26523775; PubMed Central PMCID: PMC4666835. 

Latendresse SJ, Henry DB, Aggen SH, Byck GR, Ashbeck AW, Bolland JM, Sun C, Riley BP, Mustanski B, Dick DM. Dimensionality and Genetic Correlates of Problem Behavior in Low-Income African American Adolescents. J Clin Child Adolesc Psychol. 2015 Oct 29:1-16. [Epub ahead of print] PubMed PMID: 26514393. 

Vilhjálmsson BJ, Yang J, Finucane HK, Gusev A, Lindström S, Ripke S, Genovese G, Loh PR, Bhatia G, Do R, Hayeck T, Won HH; Schizophrenia Working Group of the Psychiatric Genomics Consortium, Discovery, Biology, and Risk of Inherited Variants in Breast Cancer (DRIVE) study, Kathiresan S, Pato M, Pato C, Tamimi R, Stahl E, Zaitlen N, Pasaniuc B, Belbin G, Kenny EE, Schierup MH, De Jager P, Patsopoulos NA, McCarroll S, Daly M, Purcell S, Chasman D, Neale B, Goddard M, Visscher PM, Kraft P, Patterson N, Price AL. Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores. Am J Hum Genet. 2015 Oct 1; 97(4): 576-92. doi: 10.1016/j.ajhg.2015.09.001. PubMed PMID: 26430803; PubMed Central PMCID: PMC4596916. 

Lee D, Williamson VS, Bigdeli TB, Riley BP, Webb BT, Fanous AH, Kendler KS, Vladimirov VI, Bacanu SA. JEPEGMIX: gene-level joint analysis of functional SNPs in cosmopolitan cohorts. Bioinformatics. 2016 Jan 15; 32(2):295-7. doi: 10.1093/bioinformatics/btv567. Epub 2015 Oct 1. PubMed PMID: 26428293; PubMed Central PMCID: PMC4708106.

Mamdani M, Williamson V, McMichael GO, Blevins T, Aliev F, Adkins A, Hack L, Bigdeli T, D van der Vaart A, Web BT, Bacanu SA, Kalsi G; COGA Consortium, Kendler KS, Miles MF, Dick D, Riley BP, Dumur C, Vladimirov VI. Integrating mRNA and miRNA Weighted Gene Co-Expression Networks with eQTLs in the Nucleus Accumbens of Subjects with Alcohol Dependence. PLoS One. 2015 Sep 18; 10(9):e0137671. doi: 10.1371/ journal.pone.0137671. eCollection 2015. PubMed PMID: 26381263; PubMed Central PMCID: PMC4575063. 

Edwards AC, Bigdeli TB, Docherty AR, Bacanu S, Lee D, de Candia TR, Moscati A, Thiselton DL, Maher BS, Wormley BK; Molecular Genetics of Schizophrenia Collaboration (MGS), Walsh D, O'Neill FA, Kendler KS, Riley BP, Fanous AH. Meta-analysis of Positive and Negative Symptoms Reveals Schizophrenia Modifier Genes. Schizophr Bull. 2016 Mar; 42 (2):279-87. doi: 10.1093/schbul/sbv119. Epub 2015 Aug 27. PubMed PMID: 26316594; PubMed Central PMCID: PMC4753595. 

Lee D, Bigdeli TB, Williamson VS, Vladimirov VI, Riley BP, Fanous AH, Bacanu SA. DISTMIX: direct imputation of summary statistics for unmeasured SNPs from mixed ethnicity cohorts. Bioinformatics. 2015 Oct 1; 31(19):3099-104. doi: 10.1093/ bioinformatics/btv348. Epub 2015 Jun 9. PubMed PMID: 26059716; PubMed Central PMCID: PMC4576696. 

Docherty AR, Bigdeli TB, Edwards AC, Bacanu S, Lee D, Neale MC, Wormley BK, Walsh D, O'Neill FA, Riley BP, Kendler KS, Fanous AH. Genome-wide gene pathway analysis of psychotic illness symptom dimensions based on a new schizophrenia-specific model of the OPCRIT. Schizophr Res. 2015 May; 164(1-3):181-6. doi: 10.1016/j.schres.2015.02.013. Epub 2015 Mar 13. PubMed PMID: 25778617; PubMed Central PMCID: PMC4409533. 

Mathies LD, Blackwell GG, Austin MK, Edwards AC, Riley BP, Davies AG, Bettinger JC. SWI/SNF chromatin remodeling regulates alcohol response behaviors in Caenorhabditis elegans and is associated with alcohol dependence in humans. Proc Natl Acad Sci U S A. 2015 Mar 10; 112(10):3032-7. doi: 10.1073/pnas.1413451112. Epub 2015 Feb 23. PubMed PMID: 25713357; PubMed Central PMCID: PMC4364201.