B. Todd Webb

Principle Investigator, Analytic and Informatics Core
Assistant Professor, Department of Psychiatry
Virginia Commonwealth University
E-mail: bradley.webb@vcuhealth.org
Phone: 804-828-8133

Statistical genetics, bioinformatics, analysis of genome-wide association and sequencing data

Putman AH, Wolen AR, Harenza J, Yordanova RK, Webb BT, Chesler EJ, Miles MF. Identification of Quantitative Trait Loci and Candidate Genes for an Anxiolytic-like Response to Ethanol in BXD Recombinant Inbred Strains. Genes Brain Behav. 2016 Mar 7. doi: 10.1111/gbb.12289. [Epub ahead of print] PubMed PMID: 26948279. 

Sekar A, Bialas AR, de Rivera H, Davis A, Hammond TR, Kamitaki N, Tooley K, Presumey J, Baum M, Van Doren V, Genovese G, Rose SA, Handsaker RE; Schizophrenia Working Group of the Psychiatric Genomics Consortium, Daly MJ, Carroll MC, Stevens B, McCarroll SA. Schizophrenia risk from complex variation of complement component 4. Nature. 2016 Feb 11; 530(7589):177-83. doi: 10.1038/nature16549. Epub 2016 Jan 27. PubMed PMID: 26814963; PubMed Central PMCID: PMC4752392. 

Loh PR, Bhatia G, Gusev A, Finucane HK, Bulik-Sullivan BK, Pollack SJ; Schizophrenia Working Group of Psychiatric Genomics Consortium, de Candia TR, Lee SH, Wray NR, Kendler KS, O'Donovan MC, Neale BM, Patterson N, Price AL. Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis. Nat Genet. 2015 Dec; 47(12):1385-92. doi: 10.1038/ng.3431. Epub 2015 Nov 2. PubMed PMID: 26523775; PubMed Central PMCID: PMC4666835. 

Vilhjálmsson BJ, Yang J, Finucane HK, Gusev A, Lindström S, Ripke S, Genovese G, Loh PR, Bhatia G, Do R, Hayeck T, Won HH; Schizophrenia Working Group of the Psychiatric Genomics Consortium, Discovery, Biology, and Risk of Inherited Variants in Breast Cancer (DRIVE) study, Kathiresan S, Pato M, Pato C, Tamimi R, Stahl E, Zaitlen N, Pasaniuc B, Belbin G, Kenny EE, Schierup MH, De Jager P, Patsopoulos NA, McCarroll S, Daly M, Purcell S, Chasman D, Neale B, Goddard M, Visscher PM, Kraft P, Patterson N, Price AL. Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores. Am J Hum Genet. 2015 Oct 1; 97(4):576-92. doi: 10.1016/j.ajhg.2015.09.001. PubMed PMID: 26430803; PubMed Central PMCID: PMC4596916. 

Lee D, Williamson VS, Bigdeli TB, Riley BP, Webb BT, Fanous AH, Kendler KS, Vladimirov VI, Bacanu SA. JEPEGMIX: gene-level joint analysis of functional SNPs in cosmopolitan cohorts. Bioinformatics. 2016 Jan 15; 32(2):295-7. doi: 10.1093/bioinformatics/btv567. Epub 2015 Oct 1. PubMed PMID: 26428293; PubMed Central PMCID: PMC4708106. 

Bulik-Sullivan BK, Loh PR, Finucane HK, Ripke S, Yang J; Schizophrenia Working Group of the Psychiatric Genomics Consortium, Patterson N, Daly MJ, Price AL, Neale BM. LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat Genet. 2015 Mar; 47(3):291-5. doi: 10.1038/ng.3211. Epub 2015 Feb 2. PubMed PMID: 25642630; PubMed Central PMCID: PMC4495769. 

Gusev A, Lee SH, Trynka G, Finucane H, Vilhjálmsson BJ, Xu H, Zang C, Ripke S, Bulik-Sullivan B, Stahl E; Schizophrenia Working Group of the Psychiatric Genomics Consortium; SWE-SCZ Consortium, Kähler AK, Hultman CM, Purcell SM, McCarroll SA, Daly M, Pasaniuc B, Sullivan PF, Neale BM, Wray NR, Raychaudhuri S, Price AL; Schizophrenia Working Group of the Psychiatric Genomics Consortium; SWE-SCZ Consortium. Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases. Am J Hum Genet. 2014 Nov 6; 95(5):535-52. doi: 10.1016/j.ajhg.2014.10.004. Epub 2014 Nov 6. PubMed PMID: 25439723; PubMed Central PMCID: PMC4225595. 

Schizophrenia Working Group of the Psychiatric Genomics Consortium. Biological insights from 108 schizophrenia-associated genetic loci. Nature. 2014 Jul 24; 511(7510):421-7. doi: 10.1038/nature13595. Epub 2014 Jul 22. PubMed PMID: 25056061; PubMed Central PMCID: PMC4112379. 

Peterson RE, Maes HH, Lin P, Kramer JR, Hesselbrock VM, Bauer LO, Nurnberger JI Jr, Edenberg HJ, Dick DM, Webb BT. On the association of common and rare genetic variation influencing body mass index: a combined SNP and CNV analysis. BMC Genomics. 2014 May 14; 15:368. doi: 10.1186/ 1471-2164-15-368. PubMed PMID: 24884913; PubMed Central PMCID: PMC4035084.

Bigdeli TB, Bacanu SA, Webb BT, Walsh D, O'Neill FA, Fanous AH, Riley BP, Kendler KS. Molecular validation of the schizophrenia spectrum. Schizophr Bull. 2014 Jan; 40(1):60-5. doi: 10.1093/schbul/sbt122. Epub 2013 Aug 22. PubMed PMID: 23970557; PubMed Central PMCID: PMC3885304.