VCU-ARC Center Director
Lead, Center Project 1
Professor, Departments of Pharmacology & Toxicology, and Neurology
Professor, Center for the Study of Biological Complexity
Virginia Commonwealth University
E-mail: michael.miles@vcuhealth.org
Phone: 804-827-4054
Use of functional genomics to understand the molecular mechanisms of experience-dependent plasticity occurring with abuse of alcohol and other drugs
1: Tatom Z, Miles MF, Palmer AA. Fifteen years of the Diversity Outbred mouse model: a review. Mamm Genome. 2026 Jan 28;37(1):28. doi: 10.1007/s00335-026-10196-6. PMID: 41606199; PMCID: PMC12852284.
2: Gottlieb S, van der Vaart A, Hassan A, Bledsoe D, Morgan A, O'Rourke B, Rogers WD, Wolstenholme JT, Miles MF. A Selective GSK3β Inhibitor, Tideglusib, Decreases Intermittent Access and Binge Ethanol Self-Administration in C57BL/6J Mice. Addict Biol. 2025 May;30(5):e70044. doi: 10.1111/adb.70044. PMID: 40390305; PMCID: PMC12089657.
3: Rogers WD, Presley A, Damaj MI, Miles MF. Identification of ethanol analgesia quantitative trait loci and candidate genes in BXD recombinant inbred mouse lines. Addict Biol. 2025 Feb;30(2):e70013. doi: 10.1111/adb.70013. PMID: 39996569; PMCID: PMC11851315.
4: Mignogna KM, Tatom Z, Macleod L, Sergi Z, Nguyen A, Michenkova M, Smith ML, Miles MF. Identification of novel genetic loci and candidate genes for progressive ethanol consumption in diversity outbred mice. Neuropsychopharmacology. 2024 Nov;49(12):1892-1904. doi: 10.1038/s41386-024-01902-6. Epub 2024 Jun 29. PMID: 38951586; PMCID: PMC11473901.
5: Gnatowski ER, Jurmain JL, Dozmorov MG, Wolstenholme JT, Miles MF. Ninein, a candidate gene for ethanol anxiolysis, shows complex exon-specific expression and alternative splicing differences between C57BL/6J and DBA/2J mice. Front Genet. 2024 Sep 11;15:1455616. doi: 10.3389/fgene.2024.1455616. PMID: 39323865; PMCID: PMC11422218.
6: Rogers WD, Moncayo L, Akbar Z, Cruz M, Dahman AR, Mohiuddin A, Damaj MI, Miles MF. Transcriptomic and network analyses of an alcohol-induced peripheral neuropathy model identify putative role for histone demethylase Jmjd1c. bioRxiv [Preprint]. 2025 Oct 7:2025.10.06.680792. doi: 10.1101/2025.10.06.680792. PMID: 41279904; PMCID: PMC12632415.
7: Smith ML, Mignogna KM, Rokita JL, MacLeod L, Damaj MI, Miles MF. Identification of candidate genes for nicotine withdrawal in C57BL/6J × DBA/2J recombinant inbred mice. Genes Brain Behav. 2023 Apr;22(2):e12844. doi: 10.1111/gbb.12844. Epub 2023 Feb 13. PMID: 36781202; PMCID: PMC10067406.
8: van der Vaart A, Meng X, Bowers MS, Batman AM, Aliev F, Farris SP, Hill JS, Green TA, Dick D; and the COGA Consortium; Wolstenholme JT, Miles MF. Glycogen synthase kinase 3 beta regulates ethanol consumption and is a risk factor for alcohol dependence. Neuropsychopharmacology. 2018 Dec;43(13):2521-2531. doi: 10.1038/s41386-018-0202-x. Epub 2018 Sep 6. PMID: 30188517; PMCID: PMC6224501.
9: Weston RM, Schmitt RE, Grotewiel M, Miles MF. Transcriptome analysis of chloride intracellular channel knockdown in Drosophila identifies oxidation-reduction function as possible mechanism of altered sensitivity to ethanol sedation. PLoS One. 2021 Jul 6;16(7):e0246224. doi: 10.1371/journal.pone.0246224. PMID: 34228751; PMCID: PMC8259981.
10: Bogenpohl JW, Weston RM, Foreman TN, Kitchen KE, Miles MF. Chloride intracellular channel 4 (CLIC4) expression profile in the mouse medial prefrontal cortex and its regulation by ethanol. Alcohol Clin Exp Res. 2022 Jan;46(1):29-39. doi: 10.1111/acer.14754. Epub 2021 Dec 9. PMID: 34839533; PMCID: PMC8799520.
