VCU-ARC Center Director
Principle Investigator, Center Project 1
Professor, Departments of Pharmacology & Toxicology, and Neurology
Professor, Center for the Study of Bioloigcal Complexity
Virginia Commonwealth University
E-mail: michael.miles@vcuhealth.org
Phone: 804-827-4054
Use of functional genomics to understand the molecular mechanisms of experience-dependent plasticity occurring with abuse of alcohol and other drugs
Putman AH, Wolen AR, Harenza J, Yordanova RK, Webb BT, Chesler EJ, Miles MF. Identification of Quantitative Trait Loci and Candidate Genes for an Anxiolytic-like Response to Ethanol in BXD Recombinant Inbred Strains. Genes Brain Behav. 2016 Mar 7. doi: 10.1111/gbb.12289. [Epub ahead of print] PubMed PMID: 26948279.
Smith ML, Lopez MF, Archer KJ, Wolen AR, Becker HC, Miles MF. Time-Course Analysis of Brain Regional Expression Network Responses to Chronic Intermittent Ethanol and Withdrawal: Implications for Mechanisms Underlying Excessive Ethanol Consumption. PLoS One. 2016 Jan 5; 11(1):e0146257. doi: 10.1371/journal.pone.0146257. eCollection 2016. PubMed PMID: 26730594; PubMed Central PMCID: PMC4701666.
Slater CA, Jackson A, Muldoon PP, Dawson A, O'Brien M, Soll LG, Abdullah R, Carroll FI, Tapper AR, Miles MF, Banks ML, Bettinger JC, Damaj IM. Nicotine Enhances the Hypnotic and Hypothermic Effects of Alcohol in the Mouse. Alcohol Clin Exp Res. 2016 Jan; 40(1):62-72. doi: 10.1111/acer.12918. PubMed PMID: 26727524; PubMed Central PMCID: PMC4700556.
Mamdani M, Williamson V, McMichael GO, Blevins T, Aliev F, Adkins A, Hack L, Bigdeli T, D van der Vaart A, Web BT, Bacanu SA, Kalsi G; COGA Consortium, Kendler KS, Miles MF, Dick D, Riley BP, Dumur C, Vladimirov VI. Integrating mRNA and miRNA Weighted Gene Co-Expression Networks with eQTLs in the Nucleus Accumbens of Subjects with Alcohol Dependence. PLoS One. 2015 Sep 18; 10(9):e0137671. doi: 10.1371/ journal.pone.0137671. eCollection 2015. PubMed PMID: 26381263; PubMed Central PMCID: PMC4575063.
Batman AM, Miles MF. Translating Alcohol Research: Opportunities and Challenges. Alcohol Res. 2015; 37(1):7-14. Review. PubMed PMID: 26259085; PubMed Central PMCID: PMC4476605.
Farris SP, Pietrzykowski AZ, Miles MF, O'Brien MA, Sanna PP, Zakhari S, Mayfield RD, Harris RA. Applying the new genomics to alcohol dependence. Alcohol. 2015 Dec; 49(8):825-36. doi: 10.1016/j.alcohol.2015.03.001. Epub 2015 Mar 28. PubMed PMID: 25896098; PubMed Central PMCID: PMC4586299.
Padula AE, Griffin WC 3rd, Lopez MF, Nimitvilai S, Cannady R, McGuier NS, Chesler EJ, Miles MF, Williams RW, Randall PK, Woodward JJ, Becker HC, Mulholland PJ. KCNN Genes that Encode Small-Conductance Ca2+-Activated K+ Channels Influence Alcohol and Drug Addiction. Neuropsycho-pharmacology. 2015 Jul;40(8):1928-39. doi: 10.1038/ npp.2015.42. Epub 2015 Feb 9. PubMed PMID: 25662840.
Farris SP, Miles MF. Fyn-dependent gene networks in acute ethanol sensitivity. PLoS One. 2013 Nov 29;8(11):e82435. doi: 10.1371/journal.pone.0082435. eCollection 2013. PubMed PMID: 24312422; PubMed Central PMCID: PMC3843713.
Costin BN, Dever SM, Miles MF. Ethanol regulation of serum glucocorticoid kinase 1 expression in DBA2/J mouse prefrontal cortex. PLoS One. 2013 Aug 22; 8(8):e72979. doi: 10.1371/journal.pone.0072979. eCollection 2013. PubMed PMID: 23991167; PubMed Central PMCID: PMC3750005.
Vanderlinden LA, Saba LM, Kechris K, Miles MF, Hoffman PL, Tabakoff B. Whole brain and brain regional coexpression network interactions associated with predisposition to alcohol consumption. PLoS One. 2013 Jul 23;8(7):e68878. doi: 10.1371/journal.pone.0068878. Print 2013. PubMed PMID: 23894363; PubMed Central PMCID: PMC3720886.
Mulligan MK, Dubose C, Yue J, Miles MF, Lu L, Hamre KM. Expression, covariation, and genetic regulation of miRNA Biogenesis genes in brain supports their role in addiction, psychiatric disorders, and disease. Front Genet. 2013 Jul 5; 4:126. doi: 10.3389/fgene.2013.00126. eCollection 2013. PubMed PMID: 23847651; PubMed Central PMCID: PMC3701868.
