Lead, Center Project 3
Director, Pilot Core
Professor, Department of Pharmacology & Toxicology
Virginia Commonwealth University
E-mail: amy.lasek@vcuhealth.org
Phone: 804-628-8684
Alcohol Use Disorder, Molecular and Cellular Neuroscience, Brain Extracellular Matrix, Signal Transduction, Epigenetics and Transcription
Chen, W.-Y., Chen, H., Hamada, K., Gatta, E., Chen, Y., Zhang, H., Drnevich, J., Krishnan, H.R., Maienschein-Cline, M., Grayson, D.R., Pandey, S.C., & Lasek, A.W. (2021) Transcriptomics identifies STAT3 as a key regulator of hippocampal gene expression and anhedonia during withdrawal from chronic alcohol exposure. Transl. Psychiatry 11:298. PMCID: PMC8170676.
Hamada, K., Ferguson, L.B., Mayfield, R.D., Krishnan, H.R., Maienschein-Cline, M., & Lasek, A.W. (2021) Binge-like ethanol drinking activates ALK signaling and increases the expression of STAT3 target genes in the mouse hippocampus and prefrontal cortex. Genes Brain Behav. Feb 28;e12729. doi: 10.1111/gbb.12729. PMCID: PMC8944393.
Vandegrift, B.J., Hilderbrand, E.R., Satta, R., Tai, R., He, D., You, C., Coles, C., Chen, H., Brodie, M.S. & Lasek, A.W. (2020) Estrogen Receptor α Regulates Ethanol Excitation of Ventral Tegmental Area Neurons and Binge Drinking in Female Mice. J. Neurosci., 40(27):5196-5207. PMCID: PMC7329299.
He, D. & Lasek, A.W. (2020) Anaplastic lymphoma kinase regulates internalization of the dopamine D2 receptor. Mol. Pharm., 97:123-131. PMCID: PMC6964149.
Chen, H. & Lasek, A.W. (2020). Perineuronal nets in the insula regulate aversion-resistant alcohol drinking. Addict. Biol., 25(6):e12821. PMCID: PMC7032993.
Hilderbrand E.R. & Lasek, A.W. (2018) Estradiol enhances ethanol reward in female mice through activation of ERα and ERβ. Horm. Behav., 98:159-164. PMCID: PMC5829002.
Satta R., Hilderbrand E.R., & Lasek A.W. (2018) Ovarian Hormones Contribute to High Levels of Binge-Like Drinking by Female Mice. Alcohol. Clin. Exp. Res., 42(2):286-294. PMCID: PMC5785425.
Dutton, J.W., Chen, H., You, C., Brodie, M.S. & Lasek, A.W. (2016) Anaplastic lymphoma kinase (ALK) regulates binge-like drinking and dopamine receptor sensitivity in the ventral tegmental area. Addict. Biol.22(3):665-678. PMCID: PMC4940304.
Chen, H., He, D., & Lasek, A.W. (2015) Repeated Binge Drinking Increases Perineuronal Nets in the Insular Cortex. Alcohol. Clin. Exp. Res., 39(10):1930-8. PMCID: PMC4592458.
He, D., Chen, H., Muramatsu, H., & Lasek, A.W. (2015) Ethanol activates midkine and anaplastic lymphoma kinase signaling in neuroblastoma cells and in the brain. J. Neurochem., 135(3):508-21. PMCID: PMC4618084.