Animal Behavior Core
Jennifer T. Wolstenholme and Mike Grotewiel
The Behavior Core uniquely integrates behavioral testing of candidate genes and pathways identified by the ARC projects. The planned studies in the Behavior Core will advance the overall mission of the VCU-ARC through analyses in Drosophila (fruit fly) and mouse models that explore the role of newly identified high priority target genes in behavioral responses to alcohol. The Behavior Core will utilize the suite of genetic tools available in the fly model for accelerated screening of candidate genes for roles in acute ethanol sensitivity and rapid tolerance. The Behavior Core will also use a variety of genetic tools in the mouse model for more in- depth analysis of responses to acute and repeated ethanol including ethanol sensitivity, tolerance, consumption and seeking. The new knowledge generated by the Behavior Core will provide a deeper understanding of mechanisms driving behavioral responses to alcohol and thereby help lay the foundation required to develop strategies to better assess AUD risk, prevention and treatment.