Grotewiel Head Shot Full

Principle Investigator, Center Project 3
Associate Professor and Director of Graduate Admissions
Department of Human & Molecular Genetics
Virginia Commonwealth University
E-mail: michael.grotewiel@vcuhealth.org
Phone: 804-628-4086

Genetic pathways that influence ethanol sedation sensitivity in Drosophila, integration of invertebrate and human data on alcohol behavior

Grotewiel M, Bettinger JC. Drosophila and Caenorhabditis elegans as Discovery Platforms for Genes Involved in Human Alcohol Use Disorder. Alcohol Clin Exp Res. 2015 Aug; 39(8):1292-311. doi: 10.1111/acer.12785. Epub 2015 Jul 14. PubMed PMID: 26173477; PubMed Central PMCID: PMC4656040.

Sandhu S, Kollah AP, Lewellyn L, Chan RF, Grotewiel M. An inexpensive, scalable behavioral assay for measuring ethanol sedation sensitivity and rapid tolerance in Drosophila. J Vis Exp. 2015 Apr 15; (98). doi: 10.3791/52676. PubMed PMID: 25939022; PubMed Central PMCID: PMC4423423. 

Chan RF, Lewellyn L, DeLoyht JM, Sennett K, Coffman S, Hewitt M, Bettinger JC, Warrick JM, Grotewiel M. Contrasting influences of Drosophila white/mini-white on ethanol sensitivity in two different behavioral assays. Alcohol Clin Exp Res. 2014 Jun; 38(6):1582-93. doi: 10.1111/acer.12421. Epub 2014 May 30. PubMed PMID: 24890118; PubMed Central PMCID: PMC4049357. 

Jones MA, Amr S, Ferebee A, Huynh P, Rosenfeld JA, Miles MF, Davies AG, Korey CA, Warrick JM, Shiang R, Elsea SH, Girirajan S, Grotewiel M. Genetic studies in Drosophila and humans support a model for the concerted function of CISD2, PPT1 and CLN3 in disease. Biol Open. 2014 Apr 4; 3(5):342-52. doi: 10.1242/bio.20147559. PubMed PMID: 24705017; PubMed Central PMCID: PMC4021356. 

Zhao Z, Guo AY, van den Oord EJ, Aliev F, Jia P, Edenberg HJ, Riley BP, Dick DM, Bettinger JC, Davies AG, Grotewiel MS, Schuckit MA, Agrawal A, Kramer J, Nurnberger JI Jr, Kendler KS, Webb BT, Miles MF. Multi-species data integration and gene ranking enrich significant results in an alcoholism genome-wide association study. BMC Genomics. 2012; 13 Suppl 8:S16. doi: 10.1186/1471-2164-13-S8-S16. Epub 2012 Dec 17. PubMed PMID: 23282140; PubMed Central PMCID: PMC3535715. 

Alaimo JT, Davis SJ, Song SS, Burnette CR, Grotewiel M, Shelton KL, Pierce-Shimomura JT, Davies AG, Bettinger JC. Ethanol metabolism and osmolarity modify behavioral responses to ethanol in C. elegans. Alcohol Clin Exp Res. 2012 Nov; 36(11):1840-50. doi: 10.1111/j.1530-0277.2012.01799.x. Epub 2012 Apr 6. PubMed PMID: 22486589; PubMed Central PMCID: PMC3396773. 

Bhandari P, Hill JS, Farris SP, Costin B, Martin I, Chan CL, Alaimo JT, Bettinger JC, Davies AG, Miles MF, Grotewiel M. Chloride intracellular channels modulate acute ethanol behaviors in Drosophila, Caenorhabditis elegans and mice. Genes Brain Behav. 2012 Jun; 11(4):387-97. doi: 10.1111/ j.1601-183X.2012.00765.x. Epub 2012 Jan 28. PubMed PMID: 22239914; PubMed Central PMCID: PMC3527839. 

Bhandari P, Kendler KS, Bettinger JC, Davies AG, Grotewiel M. An assay for evoked locomotor behavior in Drosophila reveals a role for integrins in ethanol sensitivity and rapid ethanol tolerance. Alcohol Clin Exp Res. 2009 Oct; 33(10):1794-805. doi: 10.1111/j.1530-0277.2009.01018.x. Epub 2009 Jul 23. PubMed PMID: 19645731; PubMed Central PMCID: PMC3523311.

Grotewiel Lab 2016